The world of entertainment isn’t about glamour only but celebrities go through a lot of stress and anxiety. However, many of them still look younger as if from the years before stress ever hit their faces. Whether it’s the makeup-magic or it’s about living a balanced life, ever-young Pakistani celebrities have a story to tell.
Before we jump on to the list of Pakistani celebrities who seem to have stopped time for themselves, let’s look at some problems closely related with aging.
Pakistani Celebrities who refuse to grow old
Maria Wasti is above 40 years of age and surprisingly she still looks in her late 20s. We’ve been watching her in PTV dramas since we were kids. Now most of us are parents and Maria is still as young as she was in the golden PTV days.
Zainab Qayyum [ZQ]
ZQ or Zainab Qayyum was named the most talented model back in 2004. It’s been 10+ years and still she looks as young as she was on the day she got that award. She has been blessed with a lot of love from fans over the years. She has worked in several TV dramas and has a huge portfolio as a model. She has also appeared in music videos. She’s someone who has truly refused to age.
Mahnoor Baloch is the symbol of ‘ever young’ in Pakistan. She is the one actress who has literally defied age. She refuses to grow old. Even today, she looks like the girl who made her TV debut back in 1993 on PTV. Her first drama was Marvi where she appeared as a girl from Karachi.
This extra-ordinary singer from Pakistan is probably one of those people who have put a stop to aging since they have so much to do. she can’t afford to age. If there is another reason that’s helping her stay young, we’d love to hear from her.
The multi-talented Pakistani model and actress Nadia Hussain isn’t single as most of you would’ve thought. She’s a mother of two but I bet you can’t tell that unless you’ve seen her in that infamous morning show with her kids. She is also one of those Pakistani celebrities who have managed to stop the aging process, looking young even today.
What causes aging?
Aging is a natural process. The body starts building up from a mere sperm and continues to age until it finally dies. Death is imminent and that’s the end every body has to meet. There is no stopping. But what causes our bodies to age and eventually die?
To being understanding this topic, you need to know two different types of theories about aging.
There are numerous threories that can be classified as damage-based aging theories. These theories are based on the concept that damage accumulates through the lifespan of a living thing and causes aging. The most famous theories in this regard are the following.
- Orgel’s Hypothesis, Protein Damage and Autophagy
- Energy Metabolism and Aging
- The Free Radical Theory of Aging
- The DNA Damage Theory of Aging
The idea behind these theories is that damage eventually leads to failure of one of more systems, resulting in death. The damage that body accumulates over the years can come from healthy and unhealthy activities, food and toxins.
Orgel’s Hypothesis, Protein Damage and Autophagy
Aging has long been seen as a result of errors of many kind. An early attempt to develop a theory engulfing the genetic and protein machineries was Orgel’s hypothesis (Orgel, 1963). Essentially, his idea was that errors in transcription from DNA lead to errors in proteins which build-up over time and cause more errors in transcription, creating an amplifying loop that eventually kills the cell and leads to aging. Errors in DNA repair would also affect the accuracy of the flow of information in cells (Orgel, 1973). Indeed, damaged proteins accumulate with age, and enzymes lose catalytic activity with age (Gershon and Gershon, 1970). This can lead to cellular dysfunction and accumulation of other forms of damage. On the other hand, Orgel’s hypothesis has been regarded as unlikely to be correct for various reasons: feeding abnormal amino acids to animals to increase the number of errors in proteins does not result in a shorter lifespan (Strehler, 1999, p. 293); errors in macromolecular synthesis also do not appear to increase with age (Rabinovitch and Martin, 1982); in vitroaging cultured fibroblasts do not have increased protein errors (Harley et al., 1980)–and, in fact, cellular senescence appears to be caused by other mechanisms. Presently, Orgel’s hypothesis is largely discarded.
Energy Metabolism and Aging
In 1908, physiologist Max Rubner discovered a relationship between metabolic rate, body size, and longevity. In brief, long-lived animal species are on average bigger–as detailed before–and spend fewer calories per gram of body mass than smaller, short-lived species. The energy consumption hypothesis states that animals are born with a limited amount of some substance, potential energy, or physiological capacity and the faster they use it, the faster they will die (Hayflick, 1994). Later, this hypothesis evolved into the rate of living theory: the faster the metabolic rate, the faster the biochemical activity, the faster an organism will age. In other words, aging results from the pace at which life is lived (Pearl, 1928). This hypothesis is in accordance with the life history traits of mammals in which a long lifespan is associated with delayed development and slow reproductive rates (reviewed in Austad, 1997a & 1997b).
The Free Radical Theory of Aging
Free radicals and oxidants–such as singlet oxygen that is not a free radical–are commonly called reactive oxygen species (ROS) and are such highly reactive molecules that they can damage all sorts of cellular components (Fig. 1). ROS can originate from exogenous sources, such as ultraviolet (UV) and ionizing radiations, and from several intracellular sources. The idea that free radicals are toxic agents was first suggested by Rebeca Gerschman and colleagues (Gerschman et al., 1954). In 1956, Denham Harman developed the free radical theory of aging (Harman, 1956; Harman, 1981). Since oxidative damage of many types accumulate with age (e.g., Ames et al., 1993), the free radical theory of aging simply argues that aging results from the damage generated by ROS (reviewed in Beckman and Ames, 1998).
The DNA Damage Theory of Aging
The DNA, due to its central role in life, was bound to be implicated in aging (Fig. 2). One hypothesis then is that damage accumulation to the DNA causes aging, as first proposed by Failla in 1958 (Failla, 1958) and soon after developed by physicist Leo Szilard (Szilard, 1959). The theory has changed over the years as new types of DNA damage and mutation are discovered, and several theories of aging argue that DNA damage and/or mutation accumulation causes aging (reviewed in Gensler and Bernstein, 1981; Vijg and Dolle, 2002; Hoeijmakers, 2009; Freitas and de Magalhaes, 2011). Because DNA damage is seen as a broader theoretical framework than mutations, and DNA damage can lead to mutations, the current focus is on DNA damage and thus the theory herein is referred to as DNA damage theory of aging.
If progeroid syndromes represent a phenotype of accelerated aging then changes in DNA over time most likely play a role in aging, possibly through effects on cell dysfunction and loss that may involve stem cells (Freitas and de Magalhaes, 2011). Since many genetic perturbations affecting DNA repair do not influence aging, it is doubtful overall DNA repair is related to aging or that DNA damage accumulation alone drives aging. Understanding which aspects, if any, of DNA biology play a role in aging remains a great challenge in gerontology. Moreover, the next step to give strength to the DNA damage theory of aging would be to delay aging in mice based on enhanced DNA repair systems, but that has so far eluded researchers. In conclusion, changes in DNA over time may play an important role in aging, yet the essence of those changes and the exact mechanisms involved remain to be determined.
[If you’re interested in exploring theories of aging, please refer to this full ESSAY on aging]
Can humans learn to live eternally someday?
Aging is one of the things that humans have been obsessed with ever since they realized that death is imminent. Ancient Greeks tried to find the source of eternal life while Arab chmists spend countless years looking for a perfect chemical that would eventually stop aging.
Probably humans can beat death today, thanks to the advances in modern technology. Watch this documentary and you’ll be surprised how close we’ve come to putting a stop to the aging process.